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Neuroscience Meeting

Neuroscience Meeting

Tiel, The Netherlands • 22-23 June 2023

Tiel, The Netherlands
22-23 June 2023


  • Thursday, 22 June
  • Friday, 23 June
  • Poster presentations
  • 09:00 Registration (with Coffee & Tea)

    10:00 Opening

    10:10 Plenary Session
    Session 1: Dutch Heart Foundation Lecture
    Chair: Chun-Xia Yi (Amsterdam)

    Maiken Nedergaard  (Rochester, NY, USA) The Glymphatic system (45')

    11:00 Coffee & Tea

    11:30 Parallel Sessions A
    Session 2: Current innovations and technical developments in human brain stimulation
    Chairs: Fenne Smits & Dennis Schutter (Utrecht)

    Michael Nitsche  (Dortmund, Germany) Combination of non-invasive brain stimulation techniques to induce, and stabilize oscillatory brain activity (30')
    Lennart Verhagen  (Nijmegen) Non-invasive deep brain stimulation with ultrasound (15')
    Dorien van Blooijs  (Utrecht) Closed-loop cortical network stimulation for epilepsy patients (15')
    Sophie Fitzsimmons  (Amsterdam) Clinical and neuroimaging findings from a trial of repetitive transcranial magnetic stimulation therapy for obsessive-compulsive disorder (15')
    Dennis Schutter  (Utrecht) State-dependency in brain stimulation (15')

    Session 3: The neuroscience of (neuro)psychological interventions: what does it tell us about the vulnerability for affective disorders?
    Chairs: Marie-José van Tol (Groningen) & Ernst Koster (Ghent, Belgium)

    Ernst Koster  (Ghent, Belgium) Understanding causal mechanisms of recurrent depression: the role of information processing (30')
    Yannick Vander Zwalmen  (Ghent, Belgium) Cognitive control training for relapse prevention of depression  (15')
    Marie-José van Tol  (Groningen) A shield against depression: neurocognitive working mechanisms of preventive cognitive therapy in remitted depression (15')
    Marlijn Besten  (Groningen) Effect of therapeutic interventions on psycho-physiological dynamics of perseverative cognition in individuals at risk for depression (15')
    Erno Hermans  (Nijmegen) Ecological momentary interventions for stress resilience in vulnerable individuals (15')

    Session 4: Mechanisms underlying memory; from cells and synapses to circuits
    Chairs: Kübra Gülmez Karaca (Nijmegen) & Priyanka Rao-Ruiz (Amsterdam)

    Alcino Silva  (Los Angeles, CA, USA) Dendritic mechanisms of memory integration across time (30')
    Priyanka Rao-Ruiz  (Amsterdam) The synaptic code of memory encoding neuronal ensembles (15')
    Michel van den Oever  (Amsterdam) Experience-dependent progressive synaptic adaptations in cortical engram cells (15')
    Robbert Havekes  (Groningen) Restoring access to hidden memories in the sleep-deprived brain (15')
    Kübra Gülmez Karaca  (Nijmegen) Norepinephrine effects on memory engram specificity over time (15')

    Session 5: Alzheimer models revisited: neuroinflammation and synaptic plasticity
    Chairs: Martina Schmidt (Groningen) & Peter Sandner (Wuppertal, Germany)

    Peter Sandner  (Wuppertal, Germany) sGC stimulators and sGC activators: a new mode of action and treatment approach for neurodegenerative diseases and dementia? (30')
    Helmut Kessels  (Amsterdam) Effects of amyloid-beta on synaptic plasticity mechanisms involved in memory retrieval (15')
    Ulrich Eisel  (Groningen) Modulation of the immune response as therapeutic strategy in neurodegeneration (15')
    Amalia Dolga  (Groningen) The impact of AD PSEN1 mutations on neuronal and microglial metabolism (15')
    Martina Schmidt  (Groningen) Improving memory retrieval in Alzheimer’s disease by EPAC2: impact of neuroinflammation? (15')

    Session 6: Early life nutrition to support brain development
    Chairs: Caroline de Theije (Utrecht) & Aniko Korosi (Amsterdam)

    Michael Georgieff  (Minneapolis, MN, USA) The effects of iron deficiency and supplementation on neonatal brain development (30')
    Manon Benders  (Utrecht) The effects of early life nutrition on neurodevelopment in extremely preterm born infants (15')
    Mirjam Bloemendaal  (Nijmegen) Results by the Eat2BeNice consortium: diet and the role of the gut-brain axis in human neurodevelopment (15')
    Aniko Korosi  (Amsterdam) Early-nutritional intervention to combat against the long-term consequences of early-life adversity on mental health (15')
    Eva Hermans  (Utrecht) Early life nutritional supplementation containing docosahexaenoic acid (DHA) supports brain development after neonatal brain injury (15')

    Session 7: Tuning innate behavior through hypothalamic circuits and synapses
    Chairs: Mahesh Karnani (Amsterdam) & Alexander Jackson (Storrs, CT, USA)

    Alexander Jackson  (Storrs, CT, USA) Cellular building blocks of lateroposterior hypothalamic circuits (30')
    Silvana Valtcheva  (Cologne, Germany) Hypothalamic circuits for oxytocin release and maternal behavior (12')
    Susanne la Fleur  (Amsterdam) A striatal - lateral hypothalamic circuit in energy metabolism (12')
    Ling Shan  (Amsterdam) Systemic post-mortem evaluation of hypothalamic neuronal sleep-wake populations in narcolepsy type 1: an unexpected finding (12')
    Laura Supiot  (Utrecht) Effects of stress on Prefrontal cortical control over lateral hypothalamic feeding circuits (12')
    Mahesh Karnani  (Amsterdam) Cortico-hypothalamic projections control behavioral switching (12')

    13:00 Lunch

    14:15 Parallel Sessions B
    Session 8: A trans-diagnostic medicine-approach towards the diagnosis and treatment of CNS disorders
    Chairs: Rudy Schreiber & Conny Quaedflieg (Maastricht)

    Martien Kas  (Groningen) Linking neuropsychiatry to quantitative biology: a translational and transdiagnostic approach (30')
    Dennis Hernaus  (Maastricht) Optimizing behavioral paradigms to facilitate new understanding of Anhedonia and Reward Processing Deficits (15')
    Rudy Schreiber  (Maastricht) A roadmap for an RDoC-based approach in CNS drug discovery (15')
    Soma Makai-Bölöni  (Leiden) Development of the PsyCart: a novel RDoC based emotional test battery (15')
    Indira Tendolkar  (Nijmegen) Negative memory bias as a transdiagnostic marker of depression (15')

    Session 9: Expectations, habits and stress: recent insights in the neurobiology of motivated behavior
    Chairs: Frank Meye (Utrecht) & Marisela Morales (Baltimore, MD, USA)

    Marisela Morales  (Baltimore, MD, USA) Ventral tegmental area neuronal diversity and motivated behavior (30')
    Ingo Willuhn  (Amsterdam) A longitudinal study of dopamine signals in limbic, associative, and sensorimotor domains of the striatum during habit formation (15')
    Ioannis Koutlas  (Utrecht) Ventral tegmental area neuronal ensembles encoding stress and reward (15')
    Ruben van den Bosch  (Nijmegen) Striatal dopamine dissociates methylphenidate effects on value-based versus surprise-based reversal learning (15')
    Karin Foerde  (Amsterdam) Understanding persistent maladaptive decision making in anorexia nervosa (15')

    Session 10: Life style effects on brain regulation of energy metabolism
    Chairs: Chun-Xia Yi & Andries Kalsbeek (Amsterdam)

    Robert Henning  (Groningen) Can human hibernate? (30')
    Ayano Shiba  (Amsterdam) Know your clock: optimal exercise timing to maximise its benefits (15')
    Han Jiao  (Amsterdam) Time-restricted feeding reprograms microglial day-night immunity in the hypothalamus (15')
    Esther Speksnijder  (Amsterdam) Role of the central brain clock in the pathophysiology of insulin resistance (15')
    Jorine Geertsema  (Amsterdam) Early life factors as modulators of the progression of Alzheimer’s Disease: role for glia and lipid metabolism (15')

    Session 11: Human iPSC-derived brain cells and organoids, as relevant models for neurodegenerative diseases
    Chairs: Amalia Dolga (Groningen) & Wilma van de Berg (Amsterdam)

    Oliver Harschnitz  (Milan, Italy) SARS-CoV-2 infection causes dopaminergic neuron senescence (30')
    Bart Eggen  (Groningen) Microglia in health and disease (15')
    Kerensa Boersen  (Enschede) A stem cell-derived gut brain axis on a microfluidic chip (15')
    Martyna Grochowska  (Rotterdam) Modeling the cellular complexity of Parkinson’s disease with human organoids: progress, challenges, and promise (15')
    Angelica Sabogal  (Groningen) Species-specific metabolic reprogramming in human and mouse microglia during inflammatory pathway induction (15')

    Session 12: Fundamentals of neurodevelopmental disorders
    Chairs: Onur Basak & Carla Gomes da Silva (Utrecht)

    Carla Gomes da Silva  (Utrecht) Cells and developmental mechanisms of vulnerability in neurodevelopmental disorders  (15')
    Pelin Saglam-Metiner  (Bornova) Elucidating cell-type specific defects in Rett syndrome using microfluidic-enhanced organoid models  (15')
    Pavol Zelina  (Utrecht) Potential link between amyotrophic lateral sclerosis and neurodevelopmental processes (15')
    Marek Bartosovic  (Stockholm, Sweden) Multimodal single-cell profiling of three epigenetic modalities in the mouse brain by nanobody-based CUT&Tag (30')

    Session 13: Thinking out of the box: unravelling the complexity of the brain using different disciplines
    Chairs: Geeske van Woerden (Rotterdam) & Dimphna Meijer (Delft)

    Martijn van den Heuvel  (Amsterdam) Connecting worlds: bridging micro- and macro-scale brain circuitry in health and disease (30')
    Eliška Grepovlá  (Delft) Quantum physics methods for quantitative neuroscience (15')
    Anouk Heuvelmans  (Rotterdam) Modelling mTORopathy-related epilepsy in cultured murine hippocampal neurons using the Multi-Electrode Array (15')
    Vinicius Fonseca Hernandes  (Delft) Machine learning-assisted neuroscience data processing (15')
    Agathe Henocq  (Delft) Biochemical approaches to study the role of gylcosylation in synapse formation (15')

    15:45 Coffee & Tea

    16:00 Plenary Session
    Session 14: Societal Session: Social Safety

    17:00 Posters & drinks
    Session 15: Poster session 1

    18:30 Dinner

    20:00 Plenary Session
    Session 16: Prize winners

    21:00 Social

    Dutch Heart Foundation Lecture

    Current innovations and technical developments in human brain stimulation

    The field of human brain stimulation has been growing and developing fast over the past few years. Brain stimulation techniques are not only rapidly gaining ground in clinical care, but also in neuroscientific research. Technical and theoretical progress is opening up new ways to target specific brain processes and personalize stimulation protocols.
    In this session, we aim to provide an overview of some of the latest advancements. The session will cover developments in innovative stimulation techniques, insights in the fundamental working mechanisms of brain stimulation, and personalization of clinical applications in the fields of both psychiatry and neurology.

    The neuroscience of (neuro)psychological interventions: what does it tell us about the vulnerability for affective disorders?

    Affective Disorders (AD) are amongst the most prevalent psychiatric disorders. They are heterogenous in their etiology, symptomatology, and clinical course, making studying and treatment of AD complex. Owing to the high burden of AD on individual lives and society , there’s an urgent need for effective treatments that take in account this heterogeneity, including the risk for relapse after recovery from AD.
    Currently, several non-pharmacological preventive treatments have been proven effective in lowering the relapse risk, including preventive cognitive therapy and mindfulness-based cognitive behavioural therapy. For others, including cognitive remediation training, results look promising. Studying how these treatments work in contributing to relapse prevention provides a unique window to understand which neurocognitive processes need modification to build up relapse resilience and thus could be potential targets when treating individuals with depression and recurrence thereof. Uncovering the mechanisms is amongst the 10 focus areas to advance treatments for psychiatric disorders as agreed on by The Lancet Psychiatry Commission on “psychological treatments research in tomorrow's science” (2018).

    Mechanisms underlying memory; from cells and synapses to circuits

    Memories are physically represented in the brain within sparsely distributed ensembles of neurons activated during learning; so called engram neurons. At a circuit level, memory formation and storage is a temporal process that involves several brain regions, and the coordinated activity of engram neurons across different systems. At a cellular/synaptic level, this involves preferential co-activation of subsets of neurons and the strengthening of connections between these engram cells. In this symposium we will discuss recent advances in memory mechanisms across multiple levels of analysis. In particular, we will focus on how memories are allocated to, and structured in engram cell ensembles from synapses to circuits and examine how these processes are facilitated by epigenetic/transcriptional/translational changes within these neurons. In doing so we will further our understanding of how memories can be linked, stored, and influenced by external factors (such as sleep, emotional arousal and stress hormones).

    Alzheimer models revisited: neuroinflammation and synaptic plasticity

    Dementia is characterized by progressive decline in memory. The major cause of dementia is Alzheimer’s disease (AD). Several lines of evidence indicate that the retrieval - but not the formation - of episodic memories is impaired in early AD. Accumulation of amyloid β (Aβ) coexists with early synaptic failure in AD neuropathology, and synaptic perturbations are linked to early AD symptoms. Recent evidence indicate that Aβ deposition insufficiently explain the hallmarks of AD and lead to a paradigm shift with focus on the innate immune system. Neuroinflammation driven by extrinsic and intrinsic factors turns out to develop as a novel unique player in AD pathology. In this session, we will discuss the novel mechanisms underpinning the molecular mechanism leading to the induction of neuroinflammation and subsequent impairment of synaptic plasticity, and provide insights into potential innovative breakthroughs into findings its cause, treatment and cure. The selected speakers will provide identification of novel targets to diminish neuroinflammation and the decline in synaptic plasticity, using pharmacological screening platforms, animal models, organoids and iPSC-derived brain cells.

    Early life nutrition to support brain development

    Quantity and quality nutrition influences brain growth, maturation, and connectivity, and subsequent effects on neurodevelopment have been shown to persist into childhood and adolescence. Especially in infants at risk of impaired neurodevelopment, such as after prematurity, asphyxia or early life stress, optimal nutrition may provide protection to the brain. Now that clinical trials are investigating the beneficial effects of various nutraceuticals, we need to better understand the underlying mechanisms and select the most promising compounds. This session focusses on the effects of early life supplementation with macronutrients (such as poly-unsaturated fatty acids and pre-/probiotics) and micronutrients (such as iron) on brain development in preclinical and clinical settings. In addition, we will address underlying mechanisms including the gut microbiota and neuroinflammation. Creating a better understanding of optimal nutrition to support brain development may provide life-long benefits in infants/children at risk of impaired neurodevelopmental outcome.

    Tuning innate behavior through hypothalamic circuits and synapses

    Innate behaviors such as feeding and parenting, as well as visceral and metabolic control arise through neuronal firing in the hypothalamus. However, it is not yet known how these disparate functions are coordinated by hypothalamic cell-types. In order to address feeding disorders, the obesity epidemic, and fundamental survival behaviors, it is necessary to understand hypothalamic cell-types and their synaptic wiring, which control behavioural and visceral output. These aspects are becoming clearer due to recent advances by the researchers brought together in this session:
    Prof Jackson, the keynote speaker, is an expert on hypothalamic cell-type profiling with transcriptomics. Prof La Fleur is an expert on hypothalamic control of metabolism. Drs Karnani and Valtcheva are early-stage PI's focused on hypothalamic circuits and parenting, respectively. Ms Supiot is a final year PhD student in the group of Frank Meye focused on neural circuits underlying stress-feeding.
    Overall this session would bring together complementary expertises on hypothalamic behavioral drives and metabolic/visceral control. Moreover, the proposed session is balanced, with contributors from varying locations and career stages.

    A trans-diagnostic medicine-approach towards the diagnosis and treatment of CNS disorders

    The enormous progress in neuroscience research in recent decades has not led to the much-needed improvement in the diagnosis of mental health disorders and development of safer and more efficacious therapeutics. One important reason is the high symptomatic and biological heterogeneity of psychiatric disorders diagnosed by categorical classification systems such as the DSM-5. There is a good rationale that concentrating on single core symptoms that are biologically well understood might consist of a more viable approach. In 2009, the NIH launched an initiative for a trans-diagnostic, dimensional approach focusing on symptoms and their underlying neurobiology. This neurofunctional Research Domain Criteria (RDoC) domain initiative has gained momentum, especially in academic research in the US. The use of RDoC in trans-diagnostic medicine is in its infancy and the aims of this symposium are to 1) increase awareness of trans-diagnostic clinical science and the potential of RDoC-based dimensional approaches for the diagnosis and treatment of CNS symptoms; 2) offer a roadmap on how to use the RDoC framework to develop novel ideas for neurotherapeutics; and 3) provide examples of the use of RDoC in the clinic.

    Expectations, habits and stress: recent insights in the neurobiology of motivated behavior

    What makes some overconsume drugs or food, while others are repulsed by the very thought? Motivation is guided by expectations, influenced by habits, and shaped by internal states like stress. The midbrain and the striatum are key in these processes. Recent transformative insights have emphasized their heterogeneity, unraveled their complex wiring and revealed their diverse function, both in health and disease. This session brings together experts on this topic.

    Life style effects on brain regulation of energy metabolism

    Obesity is associated with development of type 2 diabetes and neurodegenerative diseases. Cumulative evidences have shown that the major cause of obesity is our modern 24-hour life style culture. These include the round-the-clock eating, sedentary behavior, exposure to artificial lighting in the evening, and lack of cold exposure. All these factors disrupt our intrinsic and evolutionarily preserved day-night and seasonal biological rhythms, and result in metabolic disorders. Currently, life style intervention is considered as the best population-wide anti-obesity strategy. Yet, the exact CNS mechanism underpinning these life style interventions is unclear. This session will focus on the neurobiological mechanism of hibernation towards understanding the interaction between brain and energy metabolism (keynote), the neuron-glial responses to timed-exercise or to timed-feeding, the disturbance of human brain master clock by light exposure, and the nutrient intervention to prevent metabolic disorders caused by early life stress. We expect our session will inspire researchers to search for effective and safe therapeutic approach to target brain for treating obesity and associated complications.

    Human iPSC-derived brain cells and organoids, as relevant models for neurodegenerative diseases

    Since their discovery, stem cells hold great promise as therapeutic tools for many chronic diseases. Due to low translation of the animal studies, scientists focused their research into stem cell technology, since stem cells have an unlimited capacity to divide, differentiate into specific cells and regenerate tissues. Our session includes speakers working on central nervous system, and inflammatory diseases. In the case of the human brain, this technology opens a window to observe some of the most elusive aspects of our own biology and understand molecular pathways underlying brain pathology. iPSC-derived brain cells and organoids are used to mimic various neurodegenerative diseases, or to better understand the molecular pathways linked to specific mutations leading to brain dysfunction. This session will provide a range of lectures with a focus on the generation and application of iPSC-derived brain cells and organoids in Alzheimer's disease, Parkinson's disease and brain infections. In order to provide a critical evaluation of the field, challenges and limitations of using these models are discussed as well.

    Fundamentals of neurodevelopmental disorders

    Neurodevelopmental disorders (NDDs) are a collection of rare disorders that affects an increasingly larger proportion of the society. Although there are effective therapies for some NDDs, this is no cure. This raises an urgent need to understand the fundamental mechanisms behind disease progression, which has its roots in brain development. Neurogenetic studies have identified over a thousand genes involved in NDDs, most of which are polygenic diseases. The advancement of the single cell RNA sequencing (scRNAseq) field has increased our understanding of cell types of the developing brain. Application of single cell genomics to epigenetics now enables us to reveal molecular mechanisms behind neural development and NDDs. Recent advances in organoid technologies enable us to model rare forms of NDDs in cell culture and discover defects that can only be measured in humanized models. However, modeling the disease in animal models is still necessary and important since organoids still lack the complexity of the developing brain. Combining technological innovations and collaborative efforts from multiple disciplines marks the beginning of an exciting era for deciphering the fundamentals Neurodevelopmental disorders.

    Thinking out of the box: unravelling the complexity of the brain using different disciplines

    How do we process information? How are individual neurons connected into large circuits and what are the underlying principles of neuronal activity patterns? To understand the organisational principles underlying the enormous computing power of biological neurons and networks remains one of the biggest challenges in neuroscience. To answer these questions, different labs are studying this on various levels, using a wide variety of techniques. In addition to the important and valuable work done by individual labs, a deeper understanding of the organisational principles underlying brain functioning can be achieved through collaborations between seemingly distant fields, thinking out of the box. In this session, examples of different approaches will be shown, starting with a leading neuroscientist in the field of connectomics. Additionally, we will present an example of how a collaboration between basic neurobiologists and physicists working on artificial intelligence and quantum technologies can bring science to a higher level and can aid us in understanding the formation of neuronal networks and how the brain processes information.

    Societal Session: Social Safety

    Poster session 1

    Prize winners

  • 09:00 Registration (with Coffee & Tea)

    09:30 Parallel Sessions C
    Session 17: Breakthroughs in biofeedback – innovative biofeedback applications to support emotion control and the leap towards societal impact
    Chairs: Floris Klumpers (Nijmegen) & Talma Hendler (Tel Aviv, Israel)

    Talma Hendler  (Tel Aviv, Israel) Self-neuromodulation of the reward system for improving health (30')
    Florian Krause  (Nijmegen) Strengthening real-life stress resilience with large-scale brain network neurofeedback (15')
    Abele Michela  (Nijmegen) Training stress resilience in action using a virtual reality biofeedback game in police officers (15')
    Jette Vos  (Maastricht) fMRI biofeedback to improve emotion regulation in depression and study emotional awareness (15')

    Session 18: Sleep’s role in memory
    Chairs: Lisa Genzel (Nijmegen) & Peter Meerlo (Groningen)

    Dorothy Tse  (Ormskirk, United Kingdom) A translatable model of schema learning from animals to humans (30')
    Jacqueline van der Meij  (Nijmegen) Learning evoked brain activity at a local and global scale during sleep (15')
    Sophia Wilhelm  (Groningen) Memory functions impaired by sleep deprivation: can PDE4 inhibitors save the day? (15')
    Umberto Olcese  (Amsterdam) Cortical function and sensory processing across brain states at the neuronal level (15')
    Christa van der Heijde  (Amsterdam) Targeting traumatic memories during sleep in post-traumatic stress disorder (15')

    Session 19: Novel mechanisms for understanding and treating neurodegenerative diseases
    Chairs: Vanessa Donega & Evgenia Salta (Amsterdam)

    Wei-Ting Chen  (Leuven, Belgium) Cellular resilience to Alzheimer's disease pathology (30')
    Evgenia Salta  (Amsterdam) Single-cell profiling of the human adult hippocampal neurogenic niche in Alzheimer’s disease and resilience (15')
    Luuk de Vries  (Amsterdam) Resilience to Alzheimer’s Disease: unraveling the molecular mechanisms in post-mortem tissue (15')
    Wim Mandemakers  (Rotterdam) On the role of LRP10 in neurodegenerative disease (15')
    Vanessa Donega  (Amsterdam) Transcriptomics reveal changes in gene signature in subventricular zone microglia in Parkinson’s disease (15')

    Session 20: Endoplasmic reticulum structure and function in neuronal (patho)physiology
    Chairs: Tamara Buijs (Amsterdam) & Ginny Farías (Utrecht)

    Hanieh Falahati  (New Haven, CT, USA) The enigmatic spine apparatus of synapses (30')
    Wiep Scheper  (Amsterdam) Neuron-specific translational control shift ensures proteostatic resilience during ER stress (15')
    Ha Nguyen  (Utrecht) Balance between ER tubules and cisternae contributes to neuronal development and function (15')
    Marijn Kuijpers  (Nijmegen) Axonal ER degradation regulates presynaptic neurotransmission (15')
    Max Koppers  (Utrecht) Axonal ER tubules regulate local translation via P180/RRBP1-mediated ribosome interactions (15')

    Session 21: The translational value of non-human primate neuroscience
    Chairs: Jinte Middeldorp (Rijswijk) & Chris Klink (Amsterdam)

    Philippe Hantraye  (Paris, France) Non-human primate models of neurodegenerative diseases and their use in imaging and gene therapy applications (30')
    Grace Farmiloe  (Amsterdam) Searching for the primate-specific factor behind the methylation of the repeat expansion in Fragile X syndrome (15')
    Jinte Middeldorp  (Rijswijk) Non-human primate studies to learn about brain aging and disease (15')
    Katrin Karadachka  (Nijmegen) Whole-brain macaque-human comparison of brain organization and application to the multiple demand network (15')
    Feng Wang  (Amsterdam) Electrical stimulation of monkey visual cortex for developing of a visual prosthesis device (15')

    Session 22: Mother's milk: a crucial start for healthy neurodevelopment?
    Chairs: Yvonne Willemsen (Nijmegen) & Aniko Korosi (Amsterdam)

    Ulrik Kræmer Sundekilde  (Aarhus, Denmark) Human breast milk metabolites and oligosaccharides over 24 months of lactation and their association with infant socio-emotional development (30')
    Hannah Juncker  (Amsterdam) Transmission of maternal psychopathology to child neurodevelopment: the potential role of human milk composition (15')
    Hans van Goudoever  (Amsterdam) Human milk and cognitive development in humans (15')
    Nina Bruinhof  (Nijmegen) Moment-to-moment associations between breast milk cortisol and infant crying and sleep (15')
    Yvonne Willemsen  (Nijmegen) Fucosylated human milk oligosaccharides during the first 12 postnatal weeks are associated with better executive functions in toddlers (15')

    11:00 Coffee & Tea

    11:30 Parallel Sessions D
    Session 23: Cerebral small vessel diseases: updates and perspectives
    Chairs: Sébastien Foulquier (Maastricht) & Louise van der Weerd (Leiden)

    Louise van der Weerd  (Leiden) Cerebral Amyloid Angiopathy: an update (30')
    Erik Bakker  (Amsterdam) The role of the perivascular system in brain clearance in a rat model of micro-infarcts (15')
    Gemma Solé Guardia  (Nijmegen) The impact of chronic hypertension on small vessel disease – from normal-appearing white matter to white matter hyperintensities (15')
    Elizabeth Jones  (Leuven, Belgium) MRI comparison to histology: relevance for cerebral small vessel disease (15')
    Sébastien Foulquier  (Maastricht) Hypoxic signaling in oligodendrocyte precursor cells: relevance for cerebral small vessel disease (15')

    Session 24: In control of our behavior? Cortical circuits for decision making
    Chairs: Rogier Poorthuis (Utrecht) & Nathan Marchant (Amsterdam)

    Gavan McNally  (Sydney, Australia) Choice under motivational conflict (30')
    Nathan Marchant  (Amsterdam) Role of anterior insula cortex in context-induced relapse of nicotine-seeking (15')
    Rogier Poorthuis  (Utrecht) Food decisions under stress: the role of prefrontal cortical neurons projecting to the lateral hypothalamus (15')
    Hanneke den Ouden  (Nijmegen) Cruise control or in control? Pavlovian biasing of goal-directed behaviour (15')
    James Livermore  (Nijmegen) Learning under acute threat: effects of physiological defensive responses on adaptation to unstable environments (15')

    Session 25: Generalization: a curse and a blessing
    Chairs: Lisa Wirz (Nijmegen) & Conny Quaedflieg (Maastricht)

    Tom Beckers  (Leuven, Belgium) Mechanisms and moderators of fear generalization: challenges to treating anxiety (30')
    Conny Quaedflieg  (Maastricht) Fear amnesia: intentional suppression to boost fear extinction (15')
    Wouter Cox  (Amsterdam) Time-dependent transformation of human emotional memory (15')
    Lisa Wirz  (Nijmegen) Temporal dynamics of threat-associated memory accuracy versus generalization (15')
    Laura de Nooij  (Nijmegen) Glucocorticoids to promote generalized extinction memories in PTSD (15')

    Session 26: The cognitive neuroscience of dreaming
    Chairs: Martin Dresler & Sarah Schoch (Nijmegen)

    Isabelle Arnulf  (Paris, France) Sleepwalking and REM sleep behavior disorder as models to study dreams (30')
    Mariana Pereira  (Nijmegen) Neuroarchitectural mapping of dream traits  (15')
    Jacinthe Cataldi  (Lausanne, Switzerland) Non-REM parasomnia experiences are associated with EEG signatures of dreaming (15')
    Jean Baptiste Maranci  (Amsterdam) The neural correlates of epic dreaming (15')
    Somayeh Ataei  (Bochum, Germany) The role of dreams in memory consolidation (15')

    Session 27: Don’t get too excited! Balancing excitation and inhibition in the brain
    Chairs: Lennart Niels Cornelisse & Jorge Mejias (Amsterdam)

    Julijana Gjorgjieva  (Munich, Germany) Coordinated synaptic plasticity rules establish E/I balance at sub-cellular and network levels (30')
    Corette Wierenga  (Nijmegen) Local coordination between excitatory and inhibitory synapses within dendrites (15')
    Giulia Moreni  (Amsterdam) Interactions between excitatory and multiple inhibitory neurons in a data-constrained model of a V1 cortical column (15')
    Torben van Voorst  (Amsterdam) Excitation and inhibition balance in cultured networks of human neurons (15')
    Nina Doorn  (Enschede) Computational modeling of in vitro E-I neuronal networks (15')

    Session 28: Maternal serotonin alterations: can we identify developmental benefits for the offspring?
    Chairs: Jocelien Olivier (Groningen) & Tim Oberlander (Vancouver, Canada)

    Tim Oberlander  (Vancouver, Canada) What can we learn about child development from longitudinal studies of prenatal SSRI exposure? (30')
    Jodi Pawluski  (Rennes, France) Perinatal SSRI effects on male and female offspring: implications from preclinical research (15')
    Mayerli Prado Rivera  (Groningen) Cognitive functioning after developmental SSRI exposure in male and female rats (15')
    Jocelien Olivier  (Groningen) Placental adaptations to maternal SSRI treatment (15')
    Rogerio Castro  (Nijmegen) Maternal TPH1 genotype defines offspring’s cognition and behavior (15')

    13:00 Lunch

    14:00 Plenary Session
    Session 29: Keynote Lecture
    Chair: Caroline de Theije (Utrecht)

    Michael Georgieff  (Minneapolis, MN, USA) Early life nutrition and brain development: breakthroughs, challenges and new horizons (45')

    14:45 Coffee & Tea

    15:00 Parallel Sessions E
    Session 30: Developmental trajectories of the hind- and midbrain and why we should care about them
    Chairs: Aleksandra Badura & Martijn Schonewille (Rotterdam)

    Juan Antonio Moreno-Bravo  (Alicante, Spain) Development of the cerebellar long-range projections (30')
    Simone Mesman  (Amsterdam) A role for Tcf4 in hindbrain patterning and development (15')
    Frank Meye  (Utrecht) Neuropeptide Y modulation of Locus Coeruleus controls anxiety behaviors (15')
    Catarina Osorio  (Rotterdam) Selective requirement for spontaneous activity in shaping cerebellar development and function (15')
    Ines Serra  (Rotterdam) Changes in hindbrain interneuron development in tuberous sclerosis complex (15')

    Session 31: How the brains controls appetite and food intake through altered reward processing
    Chairs: Margo Slomp & Susanne la Fleur (Amsterdam)

    James McCutcheon  (Tromsø, Norway) Exploring the neural and behavioural signatures of protein appetite (30')
    Anne Roefs  (Maastricht) Neural representations of food. More complicated and dynamic than you might think. (15')
    Esther Aarts  (Nijmegen) Inflammation, dopamine and effortful food choice (15')
    Margo Slomp  (Amsterdam) A dopamine receptor 1 expressing neuronal projection from the central amygdala to the lateral habenula mediates feeding behavior (15')
    Karlijn Kooij  (Utrecht) Ghrelin and food reward-seeking: it's all about the cue (15')

    Session 32: Neurobiological signatures of resilience in the face of severe stress
    Chairs: Mirjam van Zuiden (Utrecht) & Sanne van Rooij (Atlanta, GA, USA)

    Conny Quaedflieg  (Maastricht) Temporal dynamics of EEG microstates as marker of individual differences in chronic stress (15')
    Carolina Temporão  (Nijmegen) The epicenter of trauma resilience (15')
    Mirjam van Zuiden  (Utrecht) Interactions between prenatal exposure to the 1944-45 Dutch famine and glucocorticoid receptor polymorphisms influence later life PTSD susceptibility (15')
    Floris Klumpers  (Nijmegen) Pre-trauma neural markers of vulnerability to PTSD symptomatology in police (15')
    Sanne van Rooij  (Atlanta, GA, USA) Rethinking resilience using the r-factor: neuroimaging predictors of static and dynamic resilience following trauma (30')

    Session 33: Neurovascular unit dysfunction during aging
    Chairs: Erwin van Vliet & Annemieke Rozeboom (Amsterdam)

    Claus Pietrzik  (Mainz, Germany) The Blood-Brain Barrier in Alzheimer's Disease (30')
    Annemieke Rozeboom  (Amsterdam) Loss of capillary low-density lipoprotein receptor-related protein 1 in epilepsy and Alzheimer’s disease (15')
    Mazyar Abdollahi Nejat  (Amsterdam) Hyperexcitability of interneurons is causally involved in early neuronal network dysfunction and memory impairment in APP/PS1 mice (15')
    Emma Gerrits  (Stockholm, Sweden) Neurovascular dysfunction in GRN-associated frontotemporal dementia identified by single-nucleus RNA sequencing of human cerebral cortex (15')
    Loet Coenen  (Amsterdam) The aging human plasma proteome - implications for the neurovascular unit? (15')

    Session 34: Imaging-genetics: strengths and challenges of combining two neuroscientific fields
    Chairs: Ilan Libedinsky & Martijn van den Heuvel (Amsterdam)

    Emil Uffelmann  (Amsterdam) Primer on genome-wide association studies (15')
    Bernardo Maciel  (Amsterdam) Primer to connectomic studies (15')
    Elleke Tissink  (Amsterdam) Leveraging multivariate tools and pleiotropy for neuroimaging GWAS studies (15')
    Marieke Klein  (Nijmegen) Is there genetic overlap between the brain and psychiatric disorders and how to unravel the genetics of brain plasticity? (15')
    Emma Sprooten  (Nijmegen) Embracing gene-brain-behaviour complexity: a univariate history and multivariate future of imaging genetics (30')

    Session 35: Electrophysiological investigation of large scale neural populations
    Chairs: J. Alexander Heimel (Amsterdam) & Francesco Battaglia (Nijmegen)

    Xiaoxuan Jia  (Beijing, China) Module-based signal transmission in the mouse visual system (30')
    Frederic Michon  (Amsterdam) Hippocampal dynamics supporting observational learning (15')
    Devika Narain  (Rotterdam) Functional heterogeneity in cerebellar representations of time intervals (15')
    Guido Meijer  (Nijmegen) Serotonin modulates neural dynamics across the mouse brain (15')
    Jorrit Montijn  (Amsterdam) Novel statistical tools for large-scale neurophysiology (15')

    16:30 Posters & drinks
    Session 36: Poster session 2

    18:00 Closure DNM 23 & poster prizes

    Breakthroughs in biofeedback – innovative biofeedback applications to support emotion control and the leap towards societal impact

    Biofeedback has since long held great promise for boosting emotion regulation, however wide-spread societal applications are still lacking. Recent evidence from meta-analyses and well-powered studies have convincingly shown that biofeedback procedures can benefit emotional regulation and via that route robustly boost mental health. An important question that still remains however is how biofeedback can best be implemented to benefit society. In this symposium we will hear from 5 speakers about a variety of innovative ways to use biofeedback to change real-world emotion, behaviour and health. Specifically, we will hear about EEG fingerprint biofeedback to change amygdala activation and trauma symptoms (Hendler), about fMRI biofeedback on large scale neural network balance to tackle stress (Krause), about fMRI biofeedback to improve emotional awareness and control in depression (de Vos), about the use of smartphone-based applications to train HRV and it’s impact on emotions and premenstrual syndrome (Blaser) and about gamified HRV biofeedback embedded in an arousing action context in VR to train stress-resilience in police (Michela).

    Sleep’s role in memory

    Behavioural studies in humans and animals show that sleep is critical for memory consolidation, but the underlying cellular and molecular mechanisms are poorly understood. Understanding the physiology of sleep-dependent memory consolidation is not only key to understand the cognitive deficits linked to sleep disorders, but also how neuropathologies linked to impaired plasticity functions (e.g., neurodevelopmental and neurodegenerative disorders) may influence sleep. Converging evidence show that sleep and specific brain activity during sleep may contribute to changes in synaptic functions and plasticity, but which plasticity mechanisms are triggered during sleep is a matter of debate.

    Novel mechanisms for understanding and treating neurodegenerative diseases

    Neurodegenerative diseases, such as Alzheimer’s disease (AD) and Parkinson’s disease (PD), are progressive disorders with devastating consequences. With increased aging of our society the incidence of neurodegenerative disease, is expected to increase drastically. Therefore, there is an urgent need for novel therapies that not only relieve disease symptoms, but also modify pathology or stimulate brain repair. This session will show-case studies that are investigating cellular and molecular mechanisms underlying disease pathology for the identification of novel therapeutic targets. Our keynote speaker Dr. Chen, will kick-off the meeting with a lecture on target identification in AD using a bottom-up approach with spatial transcriptomics. Dr. Mandemakers will discuss the role of LRP10 in the development of PD using in vitro models and De Vries will discuss about the transcriptomic profiling of resilience to AD. Dr. Salta will present research on the single-cell profiling of the adult human neurogenic niche in Alzheimer’s and resilient brains and finally Dr. Donega will talk about a population of neuroprotective microglia identified in the stem cell niche of PD and the implications this may have for future therapeutic intervention.

    Endoplasmic reticulum structure and function in neuronal (patho)physiology

    The Endoplasmic Reticulum (ER) extends throughout the entire neuron and is involved in a plethora of functions, including manufacturing proteins and lipids, calcium storage, detoxification, and membrane trafficking. It is therefore no surprise that perturbations in ER functionality are associated with various neuropathologies, such as epilepsy, hereditary spastic paraplegia, and dementia. This session will provide a balanced overview of the state of the art of neuronal ER research, covering axons and dendrites, human and rodent, health and disease, development and degeneration. The speakers will present novel findings on the role of ER shape in dendritic development (Ms. Nguyen), ER degradation in presynaptic neurotransmission (Dr. Kuijpers), axonal ER in local translation (Dr. Koppers), and ER stress in Alzheimer’s disease (Dr. Scheper). Our main speaker, Dr. Falahati, is a HHMI Fellow at Yale School of Medicine. She uses interdisciplinary approaches to molecularly and morphologically characterize an enigmatic neuron-specific part of the ER, called the spine apparatus. While discovered over 60 years ago, the mechanisms of formation and function of this peculiar organelle remain a longstanding question of neuronal cell biology.

    The translational value of non-human primate neuroscience

    Preclinical or translational research in animals or cell cultures plays an important role in investigating complex biological processes. Since systematic studies or invasive procedures in humans are limited, these model systems form a crucial element, particularly in neuroscience research. Sometimes, studies of the brain require a model system that is anatomically, physiologically, or cognitively similar to humans, and non-human primates are the most suitable option. The comparison across non-human primates and humans can also provide valuable insight in evolutionary processes.
    This session will feature several highly specialized lines of non-human primate neuroscience research. Our speakers will discuss recent advances with a special focus on what their studies can tell us about the human brain, its disorders and possible treatments. The panel of speakers spans a variety of disciplines from animal models of brain diseases and aging, to in vitro brain models, neurogenomics, neurotechnology and cognitive neuroecology.

    Mother's milk: a crucial start for healthy neurodevelopment?

    Mothers milk is the first nutrition most infants receive after birth. Because early life is a susceptible life phase, it seems natural that milk contributes vastly to infant development. Mothers milk provides the infant building blocks to produce cells that contribute to bodily processes. Interestingly, milk may contribute to more than physical development only. As a matter of fact, evidence on how milk impacts future cognition and behavior is steadily increasing. Duration of breastfeeding as well as constituents of milk seem to be important for brain development. Milk may exert positive effects on future behavior and cognition via different pathways, such as the microbiota-gut-brain axis. Additionally, there are many factors that can affect maternal milk composition, such as maternal stress. Despite knowing all this, milk is one of the most under-investigated biological systems in life sciences. In this interdisciplinary session, with speakers from different institutes and at different stages of their career, we will present cutting edge milk research in longitudinal studies and discuss the relations between maternal stress and breastmilk composition, and how breastmilk composition relates to infant neurodevelopment and behavior.

    Cerebral small vessel diseases: updates and perspectives

    The study of the vascular contribution to cognitive impairment and dementia has gained importance over the last decade. While lots of insights have been gained on the mechanisms leading to cerebral small vessel diseases (cSVD), their study has reached a new level of complexity requiring a better understanding of the cellular and molecular events taking place within the neuro-glio-vascular unit.
    Our session on cerebral small vessel diseases will cover the study of hypertension-induced SVD, Cerebal Amyloid Angiopathy, the role of the perivascular system in brain clearance, and the relevance of possible imaging and plasma biomarkers.
    We aim to give a stage to researchers working at the neuro-glio-vascular interface and to promote the study of the cerebrovascular compartment within the Dutch neuroscience community.

    In control of our behavior? Cortical circuits for decision making

    Adaptive behavior allows us to seek pleasure and avoid harm, which is enabled by selecting an appropriate behavioral response to stimuli in the environment. Many goals in life, however, contain both desirable and undesirable aspects. Pleasant and aversive outcomes need to be weighed to come to a decision to approach or avoid a situation. Making these decisions is strongly influenced by the value of rewarding or aversive events in the environment and previously learned experiences. Intriguingly, the value of these events can be drastically changed in different environmental contexts or internal states like stress. Moreover, these decision-making processes are strongly affected in many psychiatric disorders like substance abuse and anxiety disorders and influenced by neuromodulators. What brain circuits enable us to make these types of decisions and what factors do they depend on is therefore currently widely investigated and debated. This symposium brings together many experts, on both rodent models and human behavior, to discuss exciting recent findings on circuits for decision-making.

    Generalization: a curse and a blessing

    The overly strong generalization of a traumatic memory is a fundamental symptom of anxiety disorders, such as posttraumatic stress disorder. Exposure therapy, one of the currently available treatment options, includes confronting patients with feared, but realistically safe, stimuli until their anxiety is reduced. Unfortunately, these newly established safety memories often do not generalize, so that in a different context or with the passage of time, the original fear returns, leading to a relapse of symptoms. Fundamental research in animals and humans and clinical studies with patients, are investigating the mechanisms of fear memory generalization, its modulation by factors such as stress hormones, as well as its interaction with other aspects of anxiety disorders, such as avoidance. In recent years, researchers have also set out to find new ways of improving the generalization of safety memories, for example through pharmacological manipulations. Gaining this knowledge will give us a better understanding of the characteristics of anxiety disorders and lay the groundwork for better and more individualized treatment methods. In this symposium, we will present recent advances on these topics.

    The cognitive neuroscience of dreaming

    Dreams have fascinated humans since the beginning of recorded history. In these past years with the global pandemic many people experienced so-called ‘COVID dreams’ which are often highly vivid and stressful. This has renewed the interest of researchers and public alike to understand dreaming and potential functions of dreams. In fact, with recent advances in neuroimaging methods and analyses as well as new experimental paradigms we been able to get new insights into the neuroscience of dreams. In this symposium we will highlight relevant research from both Dutch and international dream researchers. The keynote will focus on what sleep disorders such as REM sleep behavioral disorder can tell us about dreaming. This will be followed by four short talks that delve into dream research using different neuroscientific method such as fMRI, EEG in both healthy participants and patients. We think this symposium is of great interest to neuroscientists with diverse backgrounds.

    Don’t get too excited! Balancing excitation and inhibition in the brain

    In neural circuits a delicate balance exists between excitation and inhibition to warrant optimal information processing in the brain. Disturbance of this E/I balance has been associated with several neurodevelopmental and neuropsychiatric disorders. Mechanisms for E/I disbalance are studied in mouse models for disease, but recently also in patient IPSC-derived E/I networks in vitro. E/I balance occurs at different scales in the brain, from the network level to the cellular level, and is controlled by diverse mechanisms such as neuronal connectivity, excitability, and synaptic plasticity. In the past years, several computational models have been developed to understand how E/I balance emerges from the complex interplay of these mechanisms, and how it contributes to the efficient transfer and processing of information. This has become a great example of how close collaboration between computational and experimental neuroscientists can lead to more accurate models of brain function and how to bridge different scales in the brain. In this session we will give an overview of the latest developments in this field from mouse models and human neuronal cultures, with an even balance between computational and experimental work.

    Maternal serotonin alterations: can we identify developmental benefits for the offspring?

    Hundreds of thousands of babies are exposed to selective serotonin reuptake inhibitor (SSRI) antidepressants to treat maternal mood disturbances during pregnancy. SSRIs inhibit the reuptake of serotonin (5HT), increasing 5HT levels, both in mother and the unborn. Given 5-HT's key role in brain development, altering 5-HT levels has raised critical questions about the long-term developmental effects. In addition, effects of maternal gene expression related to 5-HT levels, including enzymes synthesizing 5-HT (tryptophan hydroxylase 1) on the offspring, are now also questioned.
    So far, research focused on determining whether prenatal SSRI exposure increases risks for the offspring. However recent clinical and preclinical findings question the link between SSRIs and increased risk of poor developmental outcomes. In fact, research is starting to show that, under particular developmental circumstances, SSRIs may protect against the effects of early exposure to maternal stress and mood.
    This symposium therefore addresses preclinical and human evidence on developmental serotonin alterations and the long-term outcomes for the offspring.

    Keynote Lecture

    Developmental trajectories of the hind- and midbrain and why we should care about them

    Increasing evidence points to the importance of the development of hind- and midbrain in shaping the structure and function of large scale brain networks. Particularly cerebellar development and the projections from the cerebellum to the midbrain and thalamus have been identified to be of great importance to the neocortex structure and function. The goal of this parallel session is to provide a comprehensive insight into the development of the cerebellum and midbrain, its projections and how they influence juvenile and adult brain structure and function. We will showcase a broad range of techniques used in developmental neuroscience to study developmental trajectories of hind- and midbrain in health and disease models. To this end, we will invite experts in the area of cerebellar and midbrain development at different career stages. Developmental neuroscience is an active sector of neuroscience spanning both fundamental and translational applications. We are therefore confident that this parallel session will appeal to a broad audience.

    How the brains controls appetite and food intake through altered reward processing

    Since obesity and associated comorbidities are a huge societal burden with the accompanying costs, it is crucial to understand how the brain regulates food intake and appetite. Therefore the interactions of food consumption and the hormones that are released upon food intake with brain functioning are currently widely investigated. The proposed session covers a wide range of topics, including the effects of nutrients (like protein and fat) or feeding-related hormones on brain functioning, with an emphasis on altered reward signaling or food cues. Furthermore, we will explore how specific circuits can be underlying overconsumption. Unique in the proposed speakers is the mix of preclinical and clinical researchers, allowing the development of translational approaches to help unravel the mysteries of overeating, both in animals and in humans. This knowledge is important to prevent rising of health-care costs and improve quality of life.

    Neurobiological signatures of resilience in the face of severe stress

    Although chronic and traumatic stress may induce psychological problems, most exposed individuals are resilient and adjust successfully. Investigating neurobiological mechanisms of resilience can provide key insights for new interventions to improve psychological outcome in the face of severe stressors. In this translational symposium we bring together innovative experimental rodent and human data with unique prospective clinical data on stress resilience. First, Quaedflieg explores the potential of EEG microstate resting state network dynamics to quantify chronic stress adaptation capacity. Secondly, Temporao addresses characteristics of traumatic memory traces (engram) and epigenetic regulation hereof in resilient mice. Third, van Zuiden addresses how prenatal famine exposure and genetic variation interact with childhood and adulthood stressors on late adulthood resilience. Fourth, Klumpers discusses the predictive value of pre-trauma cortical-subcortical interactions for later resilience in police recruits. Finally, our main speaker van Rooij presents how comprehensive functional neuroimaging early post-trauma informs on later resilience within the largest acute post-trauma prospective neuroimaging study to date.

    Neurovascular unit dysfunction during aging

    By 2050, one in six individuals will be 65 years of age or older. These numbers are important considering that the incidence of neurological disorders (such as epilepsy and Alzheimer’s Disease) increases with age. This clinical fact, and the limited availability for (preventive) treatment and the economic burden for society, increases the urgency for understanding the neuropathological mechanisms involved as well as the discovery of novel treatment targets. From this context, neurovascular unit (NVU) dysfunction during aging has gained a lot of attention. The NVU outlines the unique liaison existing among specialized neuro-glia, mural cells, the brain endothelium, and neurons and is important for brain homeostasis and regulating neuronal physiology through a continuous neuro-vascular coupling. During aging, dysfunction of the NVU can occur, leading to e.g., increased excitability and cognitive decline. In this translational session, we will focus on evidence obtained from experimental as well as clinical studies about the bidirectional association and the converging mechanisms existing between aging, increased excitability and cognitive decline. Furthermore, we will discuss potential biomarkers and novel therapeutic approaches.

    Imaging-genetics: strengths and challenges of combining two neuroscientific fields

    Magnetic resonance imaging (MRI) provides information on the brain structural and functional macroscale organization. Alterations of MRI measures have been reported in several neuropsychiatric disorders, suggesting an involvement of the macroscale brain systems in disease. Furthermore, genome-wide association studies (GWAS) have uncovered genetic factors underlying macroscale brain characteristics and neuropsychiatric disorders. Mounting evidence shows that these traits are heritable, suggesting an interplay between genes, brain, and neuropsychiatric disorders. However, brain and disease phenotypes are highly polygenic, meaning that each genetic factor explains a small fraction of the variation of these complex traits in the population. This complicates the understanding of the influence of genes on brain organization and, ultimately, disease. Thanks to large-scale collaborations it is now possible to perform imaging-genetics studies with the ability to detect these small genetic effects. In this panel we aim to introduce the methodology of GWAS, MRI, and the interdisciplinary field of imaging-genetics, providing examples of studies leveraging these two different fields to improve our understanding of the brain.

    Electrophysiological investigation of large scale neural populations

    New recording electrodes are revolutionizing neuroscience. These electrodes multiplex the signal from hundreds of recordings sites into one output channel and allow neuroscientists to record the activity of massive numbers of neurons simultaneously from multiple brain areas. This is giving unprecedented insight into how sensory information is represented and transformed by the brain into behaviour. It also comes with new challenges for data analysis and interpretation. We have invited a number of speakers that are at the forefront of this new technology. Our main speaker Xiaoxuan Jia was co-lead on the massive electrophysiological investigation of the mouse visual system of the Allen Institute and she has now established her own group at Tsinghua University. Other speakers are involved in developing techniques for freely behaving animal and closed-loop paradigms, inter-laboratory investigations and analytical method development. They cover a wide set of brain areas, but all have faced and overcome the challenges that all people setting up these new techniques are facing. All speakers have enthusiastically committed to participate.

    Poster session 2

    • Thursday .::. 22 June, 17:00

      P1.1  Unconventional mechanisms regulating Golgi‐independent protein sorting in neuronal axon
      Huey de Jong (Utrecht)

      P1.2  Influence of perinatal fluoxetine exposure on myelination during brain development
      Jenny Kuperus (Groningen)

      P1.3  Modulation of hypothalamic DNA methylation by methyldonors supplementation protects against early life stress-induced emotional dysregulation
      Natalia Schilder (Amsterdam)

      P1.4  Effect of context-dependent temporal structure on episodic memory
      Silvy Collin (Tilburg)

      P1.5  Divergent myelination patterns of deep and superficial CA1 neural microcircuits
      Cristina Boers Escuder (Amsterdam)

      P1.6  Long-term effects of norepinephrine on hippocampal inhibitory synaptic transmission
      Lianne Delwel (Nijmegen)

      P1.7  Mechanisms of nanoscale reorganization during synaptic potentiation
      Wouter Droogers (Utrecht)

      P1.8  Tuning to resonances: homeostatic plasticity in the olivocerebellar system
      Elias Fernandez Santoro (Rotterdam)

      P1.9  The effect of mGluR3 on excitatory transmission in L2/3 PCs in human and mouse neocortex 
      Anna Galakhova (Amstelveen)

      P1.10  Synapse diversity: does size matter?
      Anna Gradl (Amsterdam)

      P1.11  Biochemical approaches to study the role of gylcosylation in synapse formation
      Agathe Henocq (Delft)

      P1.12  The impact of time-restricted feeding on microglial function
      Jarne Jermei (Amsterdam)

      P1.13  Predicting pre- and postsynaptic plasticity using variance analysis
      Lucas Lumeij (Amsterdam)

      P1.14  The role of astrocytic Gs-GPCR signaling in cortical engram formation and remote memory retrieval
      Aline Mak (Amsterdam)

      P1.15  The proteomic landscape of synaptic subpopulations
      Biswajit Moharana (Amsterdam)

      P1.16  Validation and characterisation of input-specific labelling of synapses on engram cells underlying memory consolidation
      Panthea Nemat (Amsterdam)

      P1.17  The forgotten AMPA-receptor subunit: exploring the role of GluA3 in the visual cortex
      Anaïs Notario Reinoso (Amsterdam)

      P1.18  Noradrenaline modulates the excitation/inhibition balance in the perirhinal cortex
      Léa Salette (Amsterdam)

      P1.19  Organization and structure of postsynaptic exocytic zones in dendritic spines of excitatory neurons
      Dimitrios Samouil (Utrecht)

      P1.20  Identifying the molecular mechanisms of axon initial segment plasticity in organotypic slices
      Natia Shamugia (Amsterdam)

      P1.21  The role of shank3 in postsynaptic nanoscale reorganization during synaptic potentiation
      Lieke Steijvers (Utrecht)

      P1.22  Effects of stress on prefrontal cortical control over lateral hypothalamic feeding circuits
      Laura Supiot (Utrecht)

      P1.23  The role of parvalbumin interneurons in cortical memory engram function in a mouse model of Alzheimer’s disease
      Julia van Adrichem (Amsterdam)

      P1.24  Changes in microglia morphology and number in response to stress
      Celine van Wijk (Amsterdam)

      P1.25  AHCYL1 and IP3R1 are core components of excitatory presynaptic boutons
      Angela Zordan (Nijmegen)

      P1.26  Preservation of perineuronal nets linked to an intact cognitive ability in Alzheimer’s disease
      Anouck Bahnerth (Amsterdam)

      P1.27  Towards neutralization of XDP molecular phenotype by targeted repression of XDP-SVA
      Gunjan Bawne (Amsterdam)

      P1.28  Specific targeting of TNF receptor 2 with a novel agonist in the treatment of Alzheimer's disease
      Irem Bayraktaroglu (Groningen)

      P1.29  Exploring the potential of dormant neural stem cells of the adult human brain to activate in Parkinson’s disease
      Myrthe Berndsen (Amsterdam)

      P1.30  The role of the PCDHA gene cluster in actin regulation alterations in Alzheimer’s disease and depression
      Natasja Drenth (Groningen)

      P1.31  Glucocorticoid receptor antagonist CORT113176 attenuates motor and neuropathological symptoms of Huntington’s Disease in R6/2 mice
      Max Gentenaar (Leiden)

      P1.32  Role of pericytes in neurovascular changes during and after ischemic stroke
      Moeed Khokhar (Amsterdam)

      P1.33  DNA methylation-based prediction of midlife dementia risk
      Jarno Koetsier (Maastricht)

      P1.34  Neurovascular coupling is impaired in a rat model of heart failure with preserved ejection fraction
      Sara Lambrichts (Maastricht)

      P1.35  Methylomic-based molecular subtyping of Alzheimer’s Disease
      Valentin Laroche (Maastricht)

      P1.36  Demyelination reversibly alters morphology and dynamics of dendritic spines, and PV+ interneuron immunoreactivity in the mouse cortex
      Thomas Lewis (Hobart, Tasmania, Australia)

      P1.37  Deciphering molecular regulators of neuroinflammation in Alzheimer’s disease using iPSC-derived microglia
      Anita Lygeroudi (Amsterdam)

      P1.38  Neuroinflammation and -degeneration in SARS-CoV-2 infected rhesus macaques
      Juliana Nieuwland (Rijswijk)

      P1.39  Neuropathology and inflammation in non-human primates during ageing
      Erik Nutma (Rijswijk)

      P1.40  Systemic administration of a TNF Receptor 2 agonist improves neuropathology and cognitive functions in a humanized Alzheimer’s disease model
      Natalia Ortí Casañ (Groningen)

      P1.41  Systematic identification of novel miR-132 targets that regulate neurogenesis/neuroinflammation with relevance to AD
      Lara Panfilov (Amstelveen)

      P1.42  Assessing the therapeutic potential of microRNAs in Alzheimer's disease using human induced pluripotent stem cells
      Amber Penning (Amsterdam)

      P1.43  Amyloid-β driven synaptic depression requires PDZ protein interaction at AMPA-receptor subunit GluA3
      Niels Reinders (Utrecht)

      P1.44  Unraveling gut-brain mechanisms in cognitive ageing, using a multidomain lifestyle intervention and a targeted gut intervention: HELI and COMBI
      Lianne Remie (Nijmegen)

      P1.45  Multidimensional single-cell analysis of meningeal inflammation and cortical microglia in progressive multiple sclerosis
      Carla Rodriguez-Mogeda (Amsterdam)

      P1.46  Interplay between ferroptosis and Parkinson's Disease pathology
      Casandra Salinas Salinas (Groningen)

      P1.47  The effects of early n-3 PUFA supplementation on neuropathology and cognition in a mouse model for Alzheimer’s Disease
      Livija Sarauskyte (Amsterdam)

      P1.48  Cellular and molecular mapping of human adult hippocampal neurogenesis in Alzheimer’s disease
      Giorgia Tosoni (Amsterdam)

      P1.49  Dynamic changes in circulating immune cell profile in a rat model of comorbidities
      Laura Van der Taelen (Maastricht)

      P1.50  The effects of a multidomain lifestyle intervention on brain functioning in cognitive ageing: the HELI study
      Mark van Loenen (Nijmegen)

      P1.51  Comparison of white matter diffusion measures between early stage parkinson’s disease patients with and without rapid-eye-movement sleep behavior disorder using ultra-high field MRI
      Meriek Wanders (Maastricht)

      P1.52  Myelination governs sleep oscillations and cognition
      Thije Willems (Amsterdam)

      P1.53  Selective reduction of oxytocin-containing neurons in the hypothalamic paraventricular nucleus of patients with type 2 diabetes mellitus 
      Chun-Xia Yi (Amsterdam)

      P1.54  Improving memory retrieval via Epac2 activation in models of Alzheimer's Disease
      Tong Zhang (Groningen)

      P1.55  Circulating microRNAs associated to cerebrospinal fluid amyloid-β and phosphorylated tau levels as potential non-invasive biomarkers for mild cognitive impairment and Alzheimer’s disease
      Jacco Briedé (Maastricht)

      P1.56  Investigating the role of the transcription factor Pax5 in midbrain circuitry
      Alessandra De Amici (Rotterdam)

      P1.57  Identifying and targeting ‘hidden Rasopathies’ in Drosophila models of neurodevelopmental disorders
      Melanie de Wit (Nijmegen)

      P1.58  Blood circular RNA expression in trauma exposed individuals with and without major depressive disorder and/or post-traumatic stress disorder
      Karel Jansen (Amsterdam)

      P1.59  Inhibitory control of circuit maturation in the developing cortex
      Zhuoshi Liu (Rotterdam)

      P1.60  Osteopontin preconditioning as a promising strategy to potentiate mesenchymal stem cell treatment for hypoxic-ischemic encephalopathy
      Casper Pachocki (Utrecht)

      P1.61  Identification of the pathogenic mechanisms of SIN3A haploinsufficiency in Witteveen-Kolk Syndrome
      Sara Sebastiani (Nijmegen)

      P1.62  The role of microglia in Tuberous Sclerosis Complex (TSC) using human iPSC-derived neuronal networks
      Dana Vervloet (Rotterdam)

      P1.63  Effect of Tsc1 haploinsufficiency on cerebellar interneuron development and behavioral phenotype
      Yue Zhao (Rotterdam)

      P1.64  Spatiotemporal mapping of maladaptive fear memory in stress susceptible mice
      Angelos Didachos (Arnhem)

      P1.65  The effects of transcranial alternating current stimulation (tACS) on exposure therapy efficacy in veterans with post-traumatic stress disorder
      Karlijn Hendriks (Utrecht)

      P1.66  Long term effects of early life stress on the mouse hippocampal transcription profile
      Bente Hofstra (Groningen)

      P1.67  The short- and long-term effects of GHB use and GHB-coma on behaviour and working memory
      Arawa Kolossa (Nijmegen)

      P1.68  The multimorbidity of insulin-related somatic diseases and brain disorders shared a genetic etiology with the brain
      Minh Nguyen (Nijmegen)

      P1.69  Long-term trajectories of depressive symptoms in deployed military personnel
      Xandra Plas (Utrecht)

      P1.70  Evidence linking blood-based transcriptomic profiles to susceptibility to PTSD in deployed military soldiers
      Rick Reijnders (Maastricht)

      P1.71  Looking beyond labels: defining dimensional psychiatric symptom clusters with somatic measures based on large population-based genetic datasets
      Barbara Šakić (Nijmegen)

      P1.72  Levels of serotonin during brain development important for the functional interplay of instructing transmitter systems
      Marta Samina (Nijmegen)

      P1.73  Interaction between physical activity and psychological symptoms in adolescents remitted from depression and anxiety disorders
      Anneke Vuuregge (Amsterdam)

      P1.74  Principal cell types and circuit architecture of the mouse insular cortex underline its functional diversity
      Bart Jongbloets (Nijmegen)

      P1.75  Stability in reservoir computing with force learning
      Thijs van Loo (Nijmegen)

      P1.76  The effects of artificial light at night on the physiology and mood of day-active tree shrews
      Mateo Bril (Groningen)

      P1.77  Brain activation following voluntary wheel running in female Wistar rats
      Nikita Cijsouw (Amsterdam)

      P1.78  The prefrontal cortex in the driver’s seat – How cortical inputs to the lateral hypothalamus regulate natural behaviors in an automated maze
      Clara Hartmann (Amsterdam)

      P1.79  The effects of artificial light at night on sleep architecture of the day-active tree shrew
      Maik Huismans (Groningen)

      P1.80  Cerebellar encoding of temporal statistics
      Julius Koppen (Rotterdam)

      P1.81  Restoring access to hidden memories: overcoming sleep deprivation-induced deficits in memory acquisition in mice
      Eszter Rebeka Kovács (Groningen)

      P1.82  The effect of sleep deprivation on arousal threshold in barnacle geese
      Robin Pijnacker (Groningen)

      P1.83  What price do we pay for a lack of sleep? The effects of sleep deprivation on spatial working memory
      Jeroen Pragt (Groningen)

      P1.84  Sleep needed to remember someone new: the effect of sleep deprivation on long-term social recognition memory in mice
      Evgeniya Tyumeneva (Groningen)

      P1.85  Artificial light at night alters circadian rhythms and sleep architecture in the European jackdaw
      Kornelija Vitkute (Groningen)

      P1.86  Identifying stress- and reward-activated neuronal inputs to the ventral tegmental area
      Diaz Danko (Utrecht)

      P1.87  The effect of intranasal oxytocin on large-scale resting-state networks in healthy humans: a systematic review
      Evelyne Fraats (Amsterdam)

      P1.88  Brain activation following voluntary wheel running in male rats and mice
      Marene Hardonk (Amsterdam)

      P1.89  Long-COVID fatigue is associated with altered reward sensitivity during effort-based decision making
      Judith Scholing (Nijmegen)

      P1.90  The impact of adolescent or adult onset of exposure to addictive substances on the development of loss of control
      Sofie van Koppen (Leiden)

      P1.91  Neural mechanisms of spatial memory development
      Juraj Bevandić (Nijmegen)

      P1.92  Elevated corticosterone acutely after fear learning impairs remote auditory memory retrieval and alters brain network connectivity
      Niek Brosens (Amsterdam)

      P1.93  The association between diabetes and cholinergic neurons in the human nucleus basalis of Meynert
      Wei Jiang (Amsterdam)

      P1.94  Rethinking communication in patients with prolonged disorder of consciousness
      Sajad Kahali (Nijmegen)

      P1.95  Connecting micro- to macro-scale explorations of working memory
      Michail-Georgios Papachristos (Maastricht)

      P1.96  Early-life stress hampers processing of fear memories via persistent cellular, synaptic and proteomic effects
      Jeniffer Sanguino Gómez (Amsterdam)

      P1.97  A novel paradigm to study meta-cognition and information seeking in rats
      Yuheng Shi (Nijmegen)

      P1.98  The effects of pharmacologically-induced acute stress on decision making processes in military personnel
      Lukas van Herk (Utrecht)

      P1.99  The role of cognitive abilities in daily functioning among community-dwelling aging adults
      Nido Wardana (Groningen)

      P1.100  Fetal microchimerism detection: a novel machine learning approach to ddPCR analysis
      Koen Freerks (Groningen)

      P1.101  Development of a new protocol for successful transport and culture of neurospheres
      Leire Iglesias Cabeza (Utrecht)

      P1.102  A novel method for studying the functional role of cerebrocerebellar communication in freely moving mice 
      Thomas Jacobs (Rotterdam)

      P1.103  Engineering microbial rhodopsins towards better optogenetics tools
      Xin Meng (Delft)

      P1.104  Coordinated transcriptional response to fear conditioning across multiple brain regions: a spatial transcriptomics study in mice
      Joy Otten (Göttingen, Germany)

      P1.105  BrainX3: A neuroinformatic tool for interactive exploration of multimodal brain datasets
      Vivek Sharma (Nijmegen)

      P1.106  A consensus protocol for task-free anesthetized rat functional magnetic resonance imaging and data analysis
      Roël Vrooman (Nijmegen)

    • Friday .::. 23 June, 16:30

      P2.1  Regional differences in the human ventral tegmental area’s cellular composition
      Jonne Eggink (Utrecht)

      P2.2  Novel insights in the molecular profiling and connectivity of VTA GABA neurons
      Nik Heijmink (Utrecht)

      P2.3  Programming the stress response: does neuronal activity during early life stress prime later life stress responsivity?
      Anjana Madhavan (Nijmegen)

      P2.4  From playtime to brain rewiring: Risk-taking during play in the juvenile period improves cognitive flexibility of adult rats
      Emel Souiki (Utrecht)

      P2.5  Unraveling the effects of GFAP and vimentin in human brain development
      Hanne Twenhöfel (Utrecht)

      P2.6  Investigating myelin-related protein densities in rats perinatally exposed to fluoxetine
      Marije Visser (Groningen)

      P2.7  Activation of SK channels facilitates human neuronal differentiation
      Yuequ Zhang (groningen)

      P2.8  Sex-differences and brain-regions heterogeneity – Focus on microglia and PUFAs and oxylipin species 
      Federica Barban (Amsterdam)

      P2.9  The coexistence of rate and temporal encoding hypothesis in the brain: evidence from intracranial EEG data
      Raimon Bullich Vilarrubias (Nijmegen)

      P2.10  Dissecting the function of the cisternal organelle in the axon initial segment
      Lia Carvalhais (Nijmegen)

      P2.11  Fast signaling of excitatory transcriptomic types in L3 of the human cortex
      Stan Driessens (Amsterdam)

      P2.12  Clustering neocortical excitatory and inhibitory cell types based on electrophysiological features reveal subclasses
      Nishant Joshi (Nijmegen)

      P2.13  The modulatory effect of early dietary supplementation with polyphenols on the early-life stress-induced cognitive and brain plasticity alterations in male mice
      Marko Kratochvil (Amsterdam)

      P2.14  Patterning dendritic inputs: the development of dendritic domains of layer 2/3 pyramidal cells in the primary visual cortex before eye-opening
      Nina Meesters (Amsterdam)

      P2.15  Connectivity of a dorsomedial hypothalamic ensemble involved in anorexia-like states
      Laurens Schuurmans (Utrecht)

      P2.16  VGF mediates activity-dependent inhibitory plasticity among cortical parvalbumin-expressing interneurons
      Martijn Selten (London, United Kingdom)

      P2.17  The effects of early life stress on the excitation and inhibition of engram cells
      Sarah van der Zwaag (Amsterdam)

      P2.18  Drd1-expressing medium spiny neurons in the medial shell nucleus accumbens innervate more than half of orexin neurons in the lateral hypothalamic area
      Astrid van Irsen (Amsterdam)

      P2.19  Anatomical characterization of the prefrontal cortex - lateral hypothalamus circuit
      Maarten Werkman (Utrecht)

      P2.20  Identifying cognitive resilience related genes among genetic risk loci of Alzheimer’s disease
      Maria Carrigan (Amsterdam)

      P2.21  Exogenous mitochondria rescue ferroptotic neuronal cells against ferroptosis
      Tingting Chen (Groningen)

      P2.22  Physiological effects of a biased angiotensin II type 1 receptor agonist on blood pressure and cerebral blood flow
      Melissa Colin (Maastricht)

      P2.24  Preventing synapse loss: The use of peptides to prevent AMPAR removal in an Alzheimer's model  
      Chiara Galizia (Utrecht)

      P2.25  Hypothalamic alterations in sporadic Amyotrophic lateral sclerosis: a post-mortem study
      Nita Alpin (Heiskanen) & Alina Ciobanu (Amsterdam)

      P2.26  Mechanisms of endocannabinoid mediated remyelination in cortical organotypic slice cultures
      Kieran Higgins (Amsterdam)

      P2.27  Exploring the clinical relevance of eye-hand coordination in dementia
      Suzanna Janssens (Rotterdam)

      P2.28  Broken balance - early impairment at inhibitory synapses in Alzheimer’s disease
      Sayyada Zehra Hasan Kazmi (Utrecht; Nijmegen)

      P2.29  Modulating aggregation of exon 1 huntingtin by adding small molecule compounds  
      Danique Laan (Groningen)

      P2.30  Effect of aging on systemic pathological features of RVCL S mutant mice
      Chelsey Linnenbank (Leiden)

      P2.31  Antagonizing α7 nicotinic acetylcholine receptor with methyllycaconitine (MLA) prevents amyloid β1-42-induced toxicity
      Ellis Nelissen (Maastricht)

      P2.32  The role of subventricular zone microglia in Parkinson’s disease
      Sara Pecoraro (Amsterdam)

      P2.33  Synergetic microRNA delivery for therapeutic targeting in Alzheimer’s disease
      Oliver Polzer (Amsterdam)

      P2.34  Investigating the effects of Aβ oligomers on presynaptic nanoscale architecture using Ten-fold Robust Expansion (TREx) microscopy
      Poorvi Ravindra (Utrecht)

      P2.35  Validating cell type-specific delivery of microRNA 124 into the murine hippocampus for a microRNA-based therapeutic approach for AD
      Ayinde Swildens (Amsterdam)

      P2.36  Functional validation of an AAV-mediated microRNA delivery system using a Dual Fluorescence Reporter Sensor (DFRS) assay
      Maria Tsakona (Amsterdam)

      P2.37  Whole-brain to spinal cord visualization of L5 axon demyelination
      Daan van den Burg (Amsterdam)

      P2.38  Phenotypic differences in carriers of pathogenic variants causing leukodystrophies – a UK Biobank study
      Hieke van der Veen (Amsterdam)

      P2.39  Identifying cell-types enriched in ASD activity during brain development
      Abdool Al-Khaledi (Utrecht)

      P2.40  In vitro 3D modeling of FOXP1 syndrome using striatal organoids
      Elena Daoutsali (Leiden)

      P2.41  Multi-parametric assays show high accuracy in ASD mouse model classification on a multi-dimensional behavioural spectrum
      Arun Karim (Rotterdam)

      P2.42  Validation of θ-γ phase-amplitude coupling as a potential EEG biomarker to assess efficacy of the anti-seizure treatment
      Georgii Krivoshein (Leiden)

      P2.43  Investigating the role of inflammation and glial cells in Phelan-McDermid syndrome pathogenesis using a shank3 full knockout mouse model
      Stephany Martina (Nijmegen)

      P2.44  Predicting treatability of cognitive deficits in intellectual disability and autism disorders using Drosophila
      Isabel Quak (Nijmegen)

      P2.45  Behavioral and imaging phenotypes in a shank3 full knockout mouse model of autism: impact of age and sex differences
      Alejandro Rivera-Olvera (Nijmegen)

      P2.46  Maladaptive daydreaming is not associated with counterfactual thought: a validation study of the German and the Dutch versions of the 16-item Maladaptive Daydreaming Scale
      Pia Breuer (Maastricht)

      P2.47  The effect of HPA-axis dyresgulation and glucocorticoid administration on strength and generalization of extinction memory
      Mariana Dos Santos Ribeiro Pais (Nijmegen)

      P2.48  Applying CRISPR/Cas9 gene editing in human iPSCs to model the role of XPO7 loss-of-function variants in schizophrenia
      Esmée Dragt (Rotterdam)

      P2.49  Interactive effects of stress and diet on the epigenome in rhesus macaques
      Johanna Kerins (Diemen)

      P2.50  Quantifying cannabis metabolites in hair: associations with self-reported use, estimated potency, and mental health
      Emese Kroon (Amsterdam)

      P2.51  Disruption of memory allocation by stress: a role for parvalbumin interneurons and endocannabinoid signalling
      Sylvie Lesuis (Amsterdam)

      P2.52  Capturing the complexity of brain connectivity with polyconnectomic scores
      Ilan Libedinsky (Amsterdam)

      P2.53  Assessing generalization and return of fear memory in rats with enhanced hypothalamic-pituitary-adrenal-axis feedback regulation
      Leonie Loomans (Nijmegen)

      P2.54  From Fear to Anxiety: the role of an extended amygdala circuit in fear generalization and anxiety-like behaviour in mice
      Ema Lopes (Nijmegen)

      P2.55  Epigenetic signature of trauma resilience: what can the trauma memory engram tell us?
      Lisa Louws (Nijmegen)

      P2.56  Alcohol use despite negative consequences: Identifying associated brain circuits and behavioural predictors in a rat model
      Allison McDonald (Amsterdam)

      P2.57  Haunted by the past: The role of sensory cue-induced trauma recall in trauma susceptibility
      Thibault Merkelijn (Nijmegen)

      P2.58  Blood circRNA expression in rhesus macaques exposed to early-life adversity
      Ita Nudelman (Belmont, MA, USA)

      P2.59  Unravelling the role of fear generalisation in linking early life stress and anxiety
      Serlina Zeldenrijk (Nijmegen)

      P2.60  Connectivity and functional contribution of a population of SST-positive neurons in the vestibular nuclei
      Miguel Angel de Jesus Cruz Elizondo (Rotterdam)

      P2.61  Role of visual experience in audiovisual integration in the visual cortex
      Ayana Kemble (Amsterdam)

      P2.62  Purkinje cell activity resonation generates rhythmic behaviors at the preferred frequency of 8 Hz
      Staf Bauer (Rotterdam)

      P2.63  Unraveling multi-site oscillation dynamics during stopping in rats
      Jordi Horst (Nijmegen)

      P2.64  Rapid implicit learning of temporal context
      Luca Mangili (Rotterdam)

      P2.65  Robotic active tactile sensing inspired by serotonergic modulation using active inference
      Filip Novicky (Nijmegen)

      P2.66  Advanced age slows learning to balance with unexpected sensorimotor delays
      Paul Christian van der Zalm (Rotterdam)

      P2.67  Associatively learned balance responses are supressed during task irrelevant conditions of human standing
      Yomna Asar (Rotterdam)

      P2.68  An integrated single-cell PVN atlas reveals functionally distinct transcriptional subtypes
      Jari Berkhout (Leiden)

      P2.69  Characterisation of neuronal ensembles related to anorexia nervosa
      Eileen Brouwer (Utrecht)

      P2.70  Endocannabinoid signaling to astrocytes in the hypothalamus modulates  feeding behavior and energy metabolism
      Daniela Herrera Moro Chao (Minneapolis, MN, USA)

      P2.71  Controversies and gaps in the Basal Ganglia research and the connectivity map
      Cansu Kucuksozen (Rotterdam)

      P2.72  Sex-dependent modulation of the hypothalamic gene expression profile by stress exposure early in life and in adulthood
      Michael Roy Vencer Malaluan (Amsterdam)

      P2.73  Recovering memories thought to be ‘lost’ in the sleep-deprived brain
      Camilla Paraciani (Groningen)

      P2.74  Benchmarking the hypothalamic pre-autonomic neurons
      Delaram Poormoghadam (Amsterdam)

      P2.75  Neural circuits of innate drives: dissecting cortico-hypothalamic circuitry
      Lotte Razenberg (Amsterdam)

      P2.76  Long-lasting effects of endocannabinoid receptor activation during adolescence on behavior
      Zayel Smit (Amsterdam)

      P2.77  Measuring play behavior in children - The validation of an ethogram for LEGO play
      Anastasija Aleksić & Savannah Pongers (Utrecht)

      P2.78  The role of Lateral Hypothalamus GABA neurons in the formation and recall of alcohol memories
      Isis Alonso-Lozares (Amsterdam)

      P2.79  Reduced nucleus accumbens activity is associated with costly fearful avoidance behaviour in humans
      Anneloes Hulsman (Nijmegen)

      P2.80  Early life stress and living in a complex environment: Positioning on the social ladder, stress coping and brain plasticity
      Rixt van der Veen (Amsterdam)

      P2.81  Serotonergic modulation of ventral hippocampus underlies sex-related differences in anxiety
      Suzanne van der Veldt (Montreal, Quebec, Canada)

      P2.82  Mapping the human ventral tegmental area on the micro- and macroscale
      Anna van Regteren Altena (Utrecht)

      P2.83  Glyoxalase 1 overexpression improves neurovascular coupling response and reduces cognitive decline in an animal model of type 1 diabetes
      Eline Berends (Maastricht)

      P2.84  Do PKU mice possess different cognitive and circadian phenotypes?
      Junfei Cao (Groningen)

      P2.85  Replicating rapid-systems consolidation in large navigational task
      Laura Clément (Nijmegen)

      P2.86  Investigating microglia-neuron interactions in organotypic slice cultures using intrinsically generated network activity and novel photocaged agents
      Viktor Al Naqib (Amsterdam)

      P2.87  NMDA activation and its involvement in memory
      Martina Lamberti (Enschede)

      P2.88  Distinct engram circuits support memory persistence depending on the intensity of a fearful experience
      Sandra Parisi (Amsterdam)

      P2.89  Restoring access to memories in the sleep-deprived brain using the PDE5 inhibitor vardenafil
      Diana Popescu (Groningen)

      P2.90  Neural mechanisms implementing emotional action control are partially distinct for social vs. non-social situations: evidence from an fMRI-based study
      Upasana Shah (Nijmegen)

      P2.91  Molecular and neuronal mechanisms underlying episodic memory maturation
      Jasmin Steudler (Nijmegen)

      P2.92  Socio-cognitive performance in a classic mouse model of phenylketonuria
      Jorick Ruben te Velde (Groningen)

      P2.93  Can we find all real effects in brain networks? On the state of statistical power in MRI connectivity studies
      Koen Helwegen (Amsterdam)

      P2.94  Transport vesicle snapshots: developing a tool for spatiotemporal mass spectrometry in polarized neurons in culture
      Noortje Kersten (Utrecht)

      P2.95  The genetic architecture of brain metabolism
      Sara Lozano Seoane (Santa Cruz de Tenerife, Spain)

      P2.96  Spreading calcium waves in hiPSC-derived neuron and astrocyte co-culture
      Bastian Meth (Leiden)

      P2.97  Manifold learning using low-distortion alignment of tangent spaces
      Johannes Nieuwenhuis (Rotterdam)

      P2.98  Functional investigation of anatomically distinct neuron types in ventrolateral periaqueductal gray
      Hugo Nusselder (Rotterdam)

      P2.99  Directed evolution of QuasAr1 for 2-photon voltage imaging
      Marco Post (Delft)

      P2.100  DNA methylation profiling of individual neurons isolated from post-mortem brain tissue using laser capture microdissection and adapted limiting dilution bisulfite pyrosequencing
      Renzo Riemens (Maastricht)

      P2.101  Functional excitation-inhibition ratio indicate near-critical oscillations across frequencies in neuronal network models and humans
      Additya Sharma (Amsterdam)

      P2.102  Single-cell RNA sequencing of astrocytes and neurons derived from human induced pluripotent stem cells
      Maurits Unkel (Rotterdam)

      P2.103  Cerebral organoids in (semi)-synthetic hydrogels; finding an alternative to Matrigel
      Roos Verdegaal (Utrecht)

      P2.104  Absolute voltage imaging in developing zebrafish
      ZhenZhen Wu (Delft)

      P2.105  The role of endothelial TGF-β pathway in comorbidities-related cerebral small vessel disease
      Xiaoyu Liang (Leuven, Belgium)

    • Posters

      The two poster sessions are scheduled for Thursday, 22 June, at 17:00 and Friday, 23 June, at 16:30.

      If your abstract is selected for a poster presentation, when preparing your poster please remember that the maximum area available is 96 x 122 cm (width x height); the poster must have a portrait format. We recommend preparing your poster in a standard A0 size (841 x 1189 mm; width x height).

      "Portrait" is fine poster should be PORTRAIT    poster should NOT be LANDSCAPE "Landscape" not...

      Your poster should be readable from a 2-metre distance; as a rough guideline, use a font size of 72 pts for your title, and a minimum of 28 pts for your text.

      Posters must be mounted on the day of the presentation only, between 08:00 and the start of the first session of the day (10:00 on Thursday, and 09:30 on Friday).

      Posters must be removed at the end of the day only: 18:45 on Thursday and within 18:30 on Friday. Posters from the Thursday session that are still up by Friday at 08:00 will be discarded by the venue personnel so that the Friday posters can be set up. Posters left behind after the conclusion of the meeting will be discarded by the venue personnel.